Lack of Association Between Adrenergic Receptor Genotypes and Survival in Heart Failure Patients Treated With Carvedilol or Metoprolol
Amy J. Sehnert, MD*,*,
Susan E. Daniels, PhD*,
Michael Elashoff, PhD*,
James A. Wingrove, PhD*,
Christopher R. Burrow, MD*,
Benjamin Horne, PhD ,
Joseph B. Muhlestein, MD, FACC,
Mark Donahue, MD ,
Stephen B. Liggett, MD ,
Jeffrey L. Anderson, MD, FACC and
William E. Kraus, MD, FACC
* CardioDx, Inc., Palo Alto, California
Departments of Cardiology and Cardiovascular Research, Intermountain Medical Center, University of Utah, Salt Lake City, Utah
Department of Medicine and Cardiology, Duke University Medical Center, Durham, North Carolina
Departments of Medicine and Physiology, University of Maryland School of Medicine, Baltimore, Maryland
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Figure 1 Kaplan-Meier Survival Curves
Kaplan-Meier curves showing the percent transplant-free survival for subjects over time (in days) for single-nucleotide polymorphisms tested. (A)
ADRB1-49. (B)
ADRB1-389. (C)
ADRB2-16. (D)
ADRB2-27. (E)
ADRA2C-del322-325 (Caucasian). (F)
ADRA2C-del322-325 (African American). Black line = homozygous major allele (0 copies minor allele); red line = heterozygous (1 copy minor allele); green line = homozygous minor allele (2 copies minor allele). Vertical tick marks on the curves represent censored subjects.
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