Determinants of Progression of Coronary Artery Calcification in Type 2 DiabetesRole of Glycemic Control and Inflammatory/Vascular Calcification Markers
Dhakshinamurthy Vijay Anand, MBBS, MRCP*, ,*,
Eric Lim, MBChB, MA, MRCP*,
Daniel Darko, MD, MRCP ,
Paul Bassett, MSc ,
David Hopkins, BSc, MBChB, FRCP||,
David Lipkin, BSc, MD, FRCP*,¶,
Roger Corder, PhD, MRPharmS and
Avijit Lahiri, MBBS, MSc, MRCP, FACC, FESC*
* Cardiac Imaging and Research Centre, Wellington Hospital, London, United Kingdom
William Harvey Research Institute at Barts and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
Department of Endocrinology, Central Middlesex Hospital, London, United Kingdom
Stats Consultancy, London, United Kingdom
|| Department of Endocrinology, Kings College Hospital, London, United Kingdom
¶ Department of Cardiology, Royal Free Hospital, London, United Kingdom
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Figure 1 Relationship Between Baseline CAC Severity and CAC Progression
(A) Progression of coronary calcium according to baseline coronary artery calcification (CAC) severity. The number of patients with CAC progression is shown in parentheses. (B) Median change in volumetric CAC score (mm3) according to baseline CAC severity. The error bars represent interquartile ranges (IQRs). FU = follow-up.
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Figure 2 Absolute Changes in CAC Scores Between the Baseline and Follow-Up Evaluation
Absolute changes in coronary artery calcification (CAC) scores between the baseline and follow-up evaluation in 241 patients. The remaining 157 patients did not have calcification at the baseline and follow-up evaluation.
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Figure 3 Multivariate Predictors of Coronary Calcium Progression
Multivariate predictors of coronary calcium progression. Black squares denote odds ratios, and the horizontal lines represent 95% confidence intervals. CAC = coronary artery calcification; HbA1c = glycated hemoglobin.
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