Implantation of an Elastic Ring at Equator of the Left Ventricle Influences Cardiac Mechanics in Experimental Acute Ventricular Dysfunction
Paolo Ferrazzi, MD*,*,
Michele Senni, MD*,
Maria R. Iascone, BSc, PhD ,
Maurizio Merlo, MD*,
Michele Triggiani, MD*,
Roberto Lorusso, MD ,
Paul Herijgers, MD ,
Jan J. Schreuder, MD||,
Samuele Pentiricci, MD*,
Attilio Iacovoni, MD* and
Eugenio Quaini, MD#
* Dipartimento Cardiovascolare Clinico e di Ricerca, Bergamo, Italy
Dipartimento Patologia Clinica, Ospedali Riuniti, Bergamo, Italy
Laboratorio di Cardiochirurgia Sperimentale, Dipartimento Cardio-Toracico, Azienda Spedali Civili, Brescia, Italy
Laboratory for Experimental Cardiac Surgery, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
|| Dipartimento Chirurgia Cardiaca, Ospedale S. Raffaele, Milano, Italy
# Fondazione Poliambulanza, Dipartimento Cardiovascolare, Brescia, Italy
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Figure 1 Schematic Representation of a Portion of the Elastic Ring During Diastole and Systole
The elastic ring is conceived to store energy in 2 different moments of the cardiac cycle: in diastole (ring expansion) and in the last part of systole (ring compression). The theoretic behavior of the elastic ring predicts that the energy stored by the ring would be returned at first during the onset of systole and later during the early diastolic phase, according to physiologic elastic behavior of a normal left ventricle (LV) chamber.
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Figure 2 Experiment Design and Photographs Showing Enlargement of LV and Implantation of the Elastic Ring
The dacron waves are parallel to long axis of the LV chamber, allowing the expansion of the patch during cardiac cycle. The elastic ring was surgically implanted at the inner surface of the LV equator. LV = left ventricle.
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Figure 4 Comparison of EDPVR, ESPVR, and PRSW of Dysfunction Group and Elastic Ring Group Versus Basal
The curves represent the mean value for each group. The top mark of each curve represents the EDV30 value. EDPVR = end-diastolic pressure–volume relationship; EDV30 = end-diastolic volume at 30 mm Hg; ESPVR = end-systolic pressure–volume relationship; PRSW = preload recruitable stroke work.
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