Advertisement






Click here for more guidelines.
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 2007; 50:1484-1490, doi:10.1016/j.jacc.2007.07.011 (Published online 21 September 2007).
© 2007 by the American College of Cardiology Foundation
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow View Cardiosource Slide Set
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Byrne, M. J.
Right arrow Articles by Lardo, A. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Byrne, M. J.
Right arrow Articles by Lardo, A. C.

Diminished Left Ventricular Dyssynchrony and Impact of Resynchronization in Failing Hearts With Right Versus Left Bundle Branch Block

Melissa J. Byrne, PhD*, Robert H. Helm, MD*, Samantapudi Daya, MD*, Nael F. Osman, PhD§,||, Henry R. Halperin, MD, MA, FAHA*,{dagger},§, Ronald D. Berger, MD, PhD*, David A. Kass, MD, FAHA*,{dagger} and Albert C. Lardo, PhD, FACC, FAHA*,{dagger},{ddagger},§,*

* Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
{dagger} Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland
{ddagger} Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
§ Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
|| Department of Electrical and Computer Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland


Figure 1
View larger version (39K):
[in this window]
[in a new window]
[Download PPT slide]
 
Figure 1 Strain Plots Comparing Mechanical Dyssynchrony in Failing Hearts With RBBB and LBBB

Temporal strain maps for (A) left bundle branch block (LBBB) + heart failure; (B) right bundle branch block (RBBB) + heart failure during right atrial pacing; (C) corresponding LBBB + heart failure strain plot; and (D) corresponding RBBB + heart failure strain plot during early and late systole.

 

Figure 2
View larger version (37K):
[in this window]
[in a new window]
[Download PPT slide]
 
Figure 2 Comparison of Regional and Global Strain in Failing Hearts With RBBB and LBBB

Time to peak strain as a percentage of R-R interval for (A) RBBB + heart failure; (B) LBBB + heart failure; and (C) the standard deviation of time to peak strain for RBBB + heart failure and LBBB + heart failure. (D) Examples of electromechanical timing delay maps for both RBBB and LBBB (see text for details). Color bar: blue = early activation; red = late activation. Data expressed as mean ± standard error of the mean. (A and B) *p < 0.001 as compared with septum; {dagger}p < 0.030 as compared with septum; {ddagger}p < 0.001 as compared with lateral wall; §p = 0.535 as compared with lateral wall. (C) *p < 0.001 compared with RBBB-heart failure. Ant. = anterior; CURE = circumferential uniformity ratio estimate; Lat. = lateral; Post. = posterior; Sept. = septal; other abbreviations as in Figure 1.

 

Figure 3
View larger version (20K):
[in this window]
[in a new window]
[Download PPT slide]
 
Figure 3 Functional and Mechanical Response to Various Modes of CRT in RBBB + HF

Effect of cardiac resynchronization therapy (CRT) in right bundle branch block (RBBB) + heart failure (HF) for all pacing combinations expressed as a percent change from right-atrial-paced baseline. *p < 0.007 compared with baseline; {dagger}p < 0.047 compared with baseline; {ddagger}p < 0.005 compared with left ventricular (LV)-only pacing; §p = 0.015 compared with LV-only pacing. BiV = biventricular; CURE = circumferential uniformity ratio estimate; dP/dtmax = maximum time derivative of left ventricular pressure; RV = right ventricular.

 




 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement