Effects of Ad5FGF-4 in Patients With AnginaAn Analysis of Pooled Data From the AGENT-3 and AGENT-4 Trials
Timothy D. Henry, MD, FACC*,
Cindy L. Grines, MD, FACC ,
Matthew W. Watkins, MD, FACC ,
Nabil Dib, MD, FACC ,
Gerald Barbeau, MD||,
Randall Moreadith, MD, PhD¶,
Tony Andrasfay¶ and
Robert L. Engler, MD¶,#,*
* Minneapolis Heart Institute Foundation, Minneapolis, Minnnesota
William Beaumont Hospital, Royal Oak, Michigan
University of Vermont, Burlington, Vermont
Cardiovascular and Stem Cell Consultants, Phoenix, Arizona
|| Hôpital Laval, Ste-Foy, Quebec, Canada
¶ Cardium Therapeutics, Inc., San Diego, California
# University of California, San Diego, California
View larger version (17K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 Change in ETT Time for All Patients
Change from baseline in total exercise time for all valid case patients (men and women) at 4 weeks, 12 weeks, and 6 months. Data are mean and standard error. ETT = exercise treadmill test; vp = viral particles.
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 Change in ETT Time at Week 12 by Gender
Change from baseline in total exercise time at week 12 by gender. Data are mean and standard error. *p < 0.05, p < 0.01, p < 0.0167 (Bonferroni correction for subgroup analysis). Abbreviations as in Figure 1.
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Change in Time to Onset of 1 mm ST-Segment Change in Female Patients
Change from baseline in time to onset of 1 mm ST-segment change in female patients. Data are mean and standard error. vp = viral particles. *p < 0.05, p < 0.0167 (Bonferroni correction for subgroup analysis).
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 4 Change in Time to Onset of Angina in Female Patients
Change from baseline in time to onset of angina in female patients. Data are mean and standard error. vp = viral particles. p < 0.01, p < 0.0167 (Bonferroni correction for subgroup analysis).
|
|
View larger version (17K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 5 CCS Class Improvement in Female Patients
Mean improvement over baseline in Canadian Cardiovascular Society (CCS) class (I to IV scale) in female patients. Data are mean and standard error. vp = viral particles. *p < 0.05, p < 0.01, p < 0.0167 (Bonferroni correction for subgroup analysis).
|
|
|
