Post-Heart Transplant Diastolic Dysfunction Is a Risk Factor for Mortality
José A. Tallaj, MD*, ,*,
James K. Kirklin, MD ,
Robert N. Brown, BS,
Barry K. Rayburn, MD*,
Robert C. Bourge, MD*,
Raymond L. Benza, MD*,
Laura Pinderski, MD, PhD*, ,
Salpy Pamboukian, MD*,
David C. McGiffin, MD and
David C. Naftel, PhD
* Cardiovascular Disease
Cardiovascular Surgery, University of Alabama at Birmingham
Department of Medicine, Birmingham VA Medical Center, Birmingham, Alabama
In memoriam. Sharon Hunt, MD, FACC, served as Guest Editor for this article
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Figure 1 RAP and Cardiac Mortality
Relationship between mean right atrial pressure (RAP) and the likelihood of subsequent cardiac mortality. The lines for each time point are essentially superimposable. The dashed lines represent the 20% confidence limits. cath = catheterization; Tx = transplant; UAB = University of Alabama at Birmingham.
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Figure 2 RAP/SV and Cardiac Mortality
Univariable depiction of the relationship between mean RAP divided by stroke volume (SV) and predicted cardiac mortality at 3 time points. Abbreviations as in Figure 1.
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Figure 3 RV DD and Cardiac Death
Actuarial survival for differing categories of right ventricular (RV) diastolic dysfunction (DD). The error bars enclose ± 1 SE. Right ventricular DD is defined in terms of RAP/SV, and at each time point (6 weeks, 6 months, 1 year) is the value of RAP/SV at which discrimination in survival is possible at p = 0.05. Abbreviations as in Figures 1 and 2.
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