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Association of Plasma Levels of F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) With Human Atherosclerosis

Erdal Cavusoglu, MD^_*,,_*, Elizabeth Kornecki, PhD, Malgorzata B. Sobocka, PhD, Anna Babinska, PhD, Yigal H. Ehrlich, PhD^||, Vineet Chopra, MD, Sunitha Yanamadala, PhD^#, Cyril Ruwende, MD, PhD^#, Moro O. Salifu, MD, Luther T. Clark, MD, FACC^_*, Calvin Eng, MD, FACC, David J. Pinsky, MD, FACC^# and Jonathan D. Marmur, MD, FACC^_*

^_* Division of Cardiology, Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York
Division of Nephrology, Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York
Department of Medicine, Bronx Veterans Affairs Medical Center, Bronx, New York
^|| Program in Neuroscience, College of Staten Island of the City University of New York, Staten Island, New York
^# Division of Cardiovascular Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan

View larger version (50K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Plasma F11R Levels as a Function of CAD Score Results are presented as mean ± SEM. There was a progressive and significant increase in plasma F11 receptor (F11R) levels with an increasing coronary artery disease (CAD) score when patients were grouped as having normal or nonobstructive disease (score of 0), mild to moderate disease (score of 1 to 3), and severe disease (score of 4 to 6). p = 0.0329 by the Wilcoxon rank-sum test.

View larger version (12K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Correlation Between Plasma F11R and TNF-alpha Levels There was a very strong and highly significant correlation (r = 0.84; p < 0.0001) between the plasma levels of tumor necrosis factor (TNF)-alpha and F11 receptor (F11R) in the entire cohort of patients, consistent with the in vitro observations that TNF-alpha increases the expression of F11R in cultured endotheial cells (6).