18Fluorodeoxyglucose Positron Emission Tomography Imaging of Atherosclerotic Plaque Inflammation Is Highly ReproducibleImplications for Atherosclerosis Therapy Trials
James H.F. Rudd, MD, PhD*,*,
Kelly S. Myers, BS*,
Sameer Bansilal, MD ,
Josef Machac, MD ,
Ash Rafique, BS,
Michael Farkouh, MD, MSc,
Valentin Fuster, MD, PhD and
Zahi A. Fayad, PhD, FACC, FAHA*
* Imaging Science Laboratories
Cardiovascular Imaging Clinical Trials Unit
Division of Nuclear Medicine, Department of Radiology
The Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, New York
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Figure 1 Mean TBR Values at First and Second Scan
Error bars indicate standard deviation. Little spontaneous change in tissue-to-background ratio (TBR) values between the two scans is noted. *p < 0.05 for the TBR of both left and right carotid artery compared with the TBR of all aortic regions. Abd = abdominal; Asc = ascending; Desc = descending.
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Figure 2 Carotid and Aortic PET/CT Images Over 2 Weeks
(A) Axial images from scan 1 and 2 of one subject's carotid artery. Computed tomography (CT) (left), positron emission tomography (PET) (middle), and fused PET/CT (right) with arrows indicating similar 18fluorodeoxyglucose (FDG) uptake in the right carotid artery at both time points. (B) Sagittal images from scan 1 and 2 of another subject's aorta. CT (left), PET (middle), and fused PET/CT (right) with arrows indicating similar FDG uptake in the aortic arch and descending aorta at both time points.
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Figure 3 Bland-Altman Plots of Interobserver, Intraobserver, and Interscan Variability
(A) Interobserver, (B) intraobserver, and (C) interscan variability. The dashed line is the mean difference between the 2 scans, while the limits of agreement are drawn as solid lines (mean difference ± 2 SD). TBR = tissue-to-background ratio.
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Figure 4 Sample Size Estimates Based on Drug Efficacy
The number of subjects needed in trials using 18fluorodeoxyglucose positron emission tomography is shown for several levels of drug effect.
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