Improved Survival of Patients With End-Stage Heart Failure Listed for Heart TransplantationAnalysis of Organ Procurement and Transplantation Network/U.S. United Network of Organ Sharing Data, 1990 to 2005
Katherine Lietz, MD, PhD* and
Leslie W. Miller, MD
Cardiovascular Division, Georgetown University, Washington Hospital Center, Washington, DC
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Figure 1 The Actuarial Survival of U.S. Heart Transplant Waiting List: Years 1990–2005
The actuarial survival on the heart transplant waiting list was calculated for 18,004 United Network of Organ Sharing (UNOS) status 1 candidates (A) and 30,978 UNOS status 2 candidates (B) listed between years 1990 and 2005 in the U.S. The results were stratified by 3 eras of listing: I (years 1990–1994), II (years 1995–1999), and III (years 2000–2005), respectively. The analyses were censored at time of transplantation, removal from the waiting list due to worsening or improvement of condition, or the day of last observation on June 1, 2006, and did not account for subsequent changes of UNOS status or temporary inactivation of status.
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Figure 2 The Survival of Candidates Who Did and Did Not Undergo Heart Transplantation: Years 1990–2005
The actuarial survival of patients who did and did not undergo heart transplantation was calculated for 18,004 United Network of Organ Sharing (UNOS) status 1 candidates (A) and 30,978 UNOS status 2 candidates (B) listed between years 1990 and 2005 in the U.S. The results were stratified by 3 eras of listing: I (years 1990–1994), II (years 1995–1999), and III (years 2000–2005), respectively. The survival was calculated from the day of listing until death on the waiting list for patients who did not undergo transplantation or death after heart transplantation. The analyses were censored at time of removal from the waiting list due to worsening or improvement of condition or the day of last observation on June 1, 2006, and did not account for subsequent changes of UNOS status or temporary inactivaion of status.
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Figure 3 The Number of UNOS Status 1 and 2 Heart Transplant Candidates Listed in the U.S.: Years 1990–2005
The number of the United Network of Organ Sharing (UNOS) status 1 candidates listed for heart transplantation in the U.S. increased from 836 patients in year 1990, to 1,159 patients in year 2005. During the same period of time the number of patients listed as UNOS status 2 decreased from 2,332 patients listed in year 1990 to 1,147 patients listed in year 2005. These trends were associated with an increased proportion of the listed-to-transplanted heart transplant candidates per calendar year from 41% in year 1990 to 77% in year 2005 (red line).
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