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Prognostic Value of B-Type Natriuretic Peptides in Patients With Stable Coronary Artery Disease

The PEACE Trial

Torbjørn Omland, MD, PhD, MPH^_*,,_*, Marc S. Sabatine, MD, MPH^,, Kathleen A. Jablonski, PhD^||, Madeline Murguia Rice, PhD^||, Judith Hsia, MD^||, Ragnhild Wergeland, MT^#, Sverre Landaas, MD, PhD^_**, Jean L. Rouleau, MD, FACC^,, Michael J. Domanski, MD, FACC, Christian Hall, MD, PhD^_*,, Marc A. Pfeffer, MD, PhD, FACC^,, Eugene Braunwald, MD, FACC^, for the PEACE Investigators

^_* Department of Medicine, Akershus University Hospital, Lorenskog, Norway
Faculty of Medicine, University of Oslo, Oslo, Norway
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts
Department of Medicine, Harvard Medical School, Boston, Massachusetts
^|| George Washington University, Rockville, Maryland, and Washington, DC
^# Department of Medical Biochemistry, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
^_** Department of Clinical Chemistry, Ullevaal University Hospital, Oslo, Norway
Montreal Heart Institute, Montreal, Quebec, Canada
Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
National Heart, Lung, and Blood Institute, Bethesda, Maryland

View larger version (15K): [in this window] [in a new window] [Download PPT slide]   Figure 1 NT-ProBNP and Cardiovascular Death Kaplan-Meier curves showing the cumulative incidence of death due to a cardiovascular cause in patients according to quartiles of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 2 NT-ProBNP and Heart Failure Kaplan-Meier curves showing the cumulative incidence of fatal or nonfatal congestive heart failure (CHF) in patients according to quartiles of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3 NT-ProBNP and Stroke Kaplan-Meier curves showing the cumulative incidence of fatal or nonfatal stroke in patients according to quartiles of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations.