Elevated Plasma Fibrinogen Level Predicts Suboptimal Response to Therapy With Both Single- and Double-Bolus Eptifibatide During Percutaneous Coronary Intervention
Ehtisham Mahmud, MD*,
Jeffrey J. Cavendish, MD,
Sotirios Tsimikas, MD,
Lawrence Ang, BS,
Cuong Nguyen, MD,
Guilherme Bromberg-Marin, MD,
Guido Schnyder, MD,
Shahin Keramati, MD,
Vachaspathi Palakodeti, MD,
William F. Penny, MD and
Anthony N. DeMaria, MD
Division of Cardiology, University of California at San Diego, San Diego, California. There was no commercial support for this study.
View larger version (18K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 Fibrinogen Level by Response to Single- and Double-Bolus Eptifibatide
(A) Fibrinogen level of optimal (OPT) and suboptimal (sub-OPT) responders with single-bolus eptifibatide. p = 0.002. (B) Fibrinogen level of OPT and sub-OPT responders with double-bolus eptifibatide. p = 0.01.
|
|
View larger version (19K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 ROC Curve Relating Fibrinogen Level and Suboptimal Platelet Inhibition to Eptifibatide
Receiver-operator characteristic (ROC) curve relating fibrinogen level and suboptimal platelet inhibition response to eptifibatide first bolus dose. AUC = area under the curve.
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Fibrinogen Levels Predictive of Suboptimal Platelet Inhibition With Eptifibatide
Fibrinogen level predictive of suboptimal response (platelet inhibition <95% as indicated by red line) to first bolus eptifibatide with 90% and 100% probability is 325 mg/dl and 375 mg/dl, respectively.
|
|
|
