Ventricular Repolarization Dynamicity Provides Independent Prognostic Information Toward Major Arrhythmic Events in Patients With Idiopathic Dilated Cardiomyopathy
Massimo Iacoviello, MD, PhD*,*,
Cinzia Forleo, MD, PhD*,
Pietro Guida, PhD*,
Roberta Romito, MD ,
Antonio Sorgente, MD*,
Sandro Sorrentino, PhD*,
Silvana Catucci, MD*,
Filippo Mastropasqua, MD and
Mariavittoria Pitzalis, MD, PhD
* Institute of Cardiology, University of Bari, Bari, Italy
Emergency Cardiology Department, University-Hospital of Bari, Bari, Italy
Division of Cardiology, "S. Maugeri" Foundation, Cassano delle Murge, Italy
Division of Cardiology, Department of Internal Medicine, The Brody School of Medicine at East Carolina University, Greenville, North Carolina
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Figure 2 Kaplan-Meier Curves According to Combinations of LVEF, NSVT, and QTe-Slope
Kaplan-Meier estimates for arrhythmia-free survival for: (A) combinations of left ventricular ejection fraction (LVEF) ( 35% or >35%) and presence or absence of nonsustained ventricular tachycardia (NSVT) (NSVT+ and NSVT–, respectively); (B) combinations of LVEF (35% or >35%) and slope of linear regression analysis of QT end and RR intervals (QTe-slope) (>0.19 or 0.19); (C) combinations of LVEF >35%, NSVT– and QTe-slope <0.19 (Group A); LVEF >35%, NSVT+ or QTe-slope >0.19 (Group B); LVEF 35%, NSVT–, and QTe-slope 0.19 (Group C); LVEF 35%, NSVT+ or QTe-slope >0.19 (Group D). No differences were observed among survival curves of patients belonging to Group A, B, and C (chi-square 1.36; p = 0.51). Only when Group D patients were included in the analysis did the comparison reach statistical significance (chi-square 20.20; p < 0.0001).
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Figure 3 Probability of Arrhythmic Events Out to 36 Months in Patients With LVEF <35%
Bar graph illustrating the probability of arrhythmic events at 36 months in patients with LVEF <35% according to the presence or absence of NSVT and QTe-slope above or below median value. The number of patients in each subgroup is reported. Abbreviations as in Figure 2.
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