Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT)A Prospective, Randomized Trial of Intracoronary Hyperoxemic Reperfusion After Percutaneous Coronary Intervention
William W. O'Neill, MD*,*,
Jack L. Martin, MD ,
Simon R. Dixon, MBChB ,
Antonio L. Bartorelli, MD ,
Daniela Trabattoni, MD,
Pranobe V. Oemrawsingh, MD||,
Douwe E. Atsma, MD||,
Michael Chang, MD¶,
William Marquardt, MD¶,
Jae K. Oh, MD#,
Mitchell W. Krucoff, MD**,
Raymond J. Gibbons, MD#,
J. Richard Spears, MD AMIHOT Investigators
* University of Miami, Miami, Florida
Sharpe-Strumia Research Foundation of the Bryn Mawr Hospital, Main Line Health System, Bryn Mawr, Pennsylvania
William Beaumont Hospital, Royal Oak, Michigan
Centro Cardiologico Monzino, University of Milan, Milan, Italy
|| Leiden University Medical Center, Leiden, the Netherlands
¶ Mercy General Hospital, Sacramento, California
# Mayo Clinic, Rochester, Minnesota
** Duke Clinical Research Institute, Durham, North Carolina
Wayne State University, Detroit, Michigan
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Figure 2 Clinical Recruitment Algorithm
AO = aqueous oxygen; FTT = failure to treat (see text for definition); IABP = intra-aortic balloon pump; MI = myocardial infarction; PCI = percutaneous coronary intervention; WMSI = wall motion score index.
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Figure 3 Echo Wall Motion Changes
Change in wall motion score index of the infarct zone at 3 months in patients assigned to undergo percutaneous coronary intervention with or without hyperoxemic reperfusion (intent-to-treat analysis). Results are shown for the overall study group and patients with anterior acute myocardial infarction (MI) <6 h. AO = aqueous oxygen group; RWM = regional wall motion.
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Figure 4 Changes in ST-Segment Elevation
The ST-segment resolution in patients assigned to undergo percutaneous coronary intervention (PCI) with or without hyperoxemic reperfusion (measured by the area under the ST-segment deviation vs. time curve 0 to 3 h after PCI; intent-to-treat analysis). Results are shown for the overall study group and patients with anterior acute myocardial infarction (MI) <6 h. A greater proportion of anterior MI patients in the aqueous oxygen (AO) group had improved ST-segment resolution compared with controls.
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Figure 5 Changes in Nuclear Infarct Size
Final infarct size at 14 days in patients assigned to undergo percutaneous coronary intervention with or without hyperoxemic reperfusion (intent-to-treat analysis). Results are shown for the overall study group and patients with anterior myocardial infarction (MI) <6 h. AO = aqueous oxygen group.
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