Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure
Christine K. Kissel, MD,
Ralf Lehmann, MD,
Birgit Assmus, MD,
Alexandra Aicher, MD,
Jörg Honold, MD,
Ulrich Fischer-Rasokat, MD,
Christopher Heeschen, MD,
Ioakim Spyridopoulos, MD,
Stefanie Dimmeler, PhD and
Andreas M. Zeiher, MD*
Department of Cardiology, Johann Wolfgang Goethe–University Frankfurt, Frankfurt, Germany
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Figure 1 Number of EPCs in CHF Patients Compared With Healthy Volunteers
Data are presented as mean ± SD. CHF = chronic heart failure; DCM = dilated cardiomyopathy; EPC = endothelial progenitor cell; ICM = ischemic cardiomyopathy; n.s. = not significant.
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Figure 2 Functional Impairment of EPCs as Assessed by VEGF-Induced Migratory Capacity
Data are presented as mean ± SD. VEGF = vascular endothelial growth factor; other abbreviations as in Figure 1.
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Figure 3 Number of Hematopoietic Precursor Cells as Assessed by FACS Analysis of Marker Proteins
The percentages of total cells are depicted as mean ± SD. FACS = fluorescent-activated cell sorting; other abbreviations as in Figure 1.
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