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The Impact of Renal Dysfunction on Outcomes in the ExTRACT-TIMI 25 Trial

Keith A.A. Fox, FRCP^_*, Elliott M. Antman, MD, FACC^,_*, Gilles Montalescot, MD, Stefan Agewall, MD, Bhupathi SomaRaju, MD^||, Freek W.A. Verheugt, MD, FACC^¶, Jose Lopez-Sendon, MD, FACC^#, Hanoch Hod, MD, FACC^_**, Sabina A. Murphy, MPH and Eugene Braunwald, MD, MACC

^_* University of Edinburgh, Edinburgh, United Kingdom
TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
Institut de Cardiologie, Pitie-Salpetriere University Hospital, Paris, France
Coronary Care Unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
^|| CARE Hospital, Hyderabad, India
^¶ University Hospital Nijmegen, Nijmegen, the Netherlands
^# Hospital Universitario La Paz Madrid, Madrid, Spain
^_** Heart Institute, Sheba Medical Center, Tel Hashomer, Israel

View larger version (18K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Relationship Between Creatinine Clearance and Outcomes Panels A to D plot the outcomes shown as estimated from a univariate regression model treating creatinine clearance (CrCl) as a continuous variable. MI = myocardial infarction.

View larger version (75K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Death or Nonfatal Recurrent MI at 30 Days in Strata of CrCl According to Treatment Assignment CrCl = creatinine clearance; ENOX = enoxaparin; MI = myocardial infarction; ORadj = odds ratio adjusted for baseline risk; UFH = unfractionated heparin.