Prognostic Value of Midregional Pro-Adrenomedullin in Patients With Acute Myocardial InfarctionThe LAMP (Leicester Acute Myocardial Infarction Peptide) Study
Sohail Q. Khan, BSc (Hons), MBChB, MRCP*,*,
Russell J. O'Brien, MBChB, MRCP*,
Joachim Struck, PhD ,
Paulene Quinn, MPhil*,
Nils Morgenthaler, PhD,
Iain Squire, MD, FRCP*,
Joan Davies, PhD, FRCP*,
Andreas Bergmann, PhD and
Leong L. Ng, MD, FRCP*
* University of Leicester, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, United Kingdom
Research Department, BRAHMS Aktiengesellschaft, Hennigsdorf, Germany
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Figure 1 Principle of the MR-proADM Assay
A sketch of the adrenomedullin (ADM) precursor is shown, and amino acid positions in preproADM are denoted at which the precursor is proteolytically processed. Tracer- and solid phase–antibodies used in the sandwich immunoassay for the detection of midregional pro-adrenomedullin (MR-proADM) are indicated. PAMP = pro-adrenomedullin N-terminal 20 peptide; signal = signal peptide.
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Figure 2 Combined ROC Curve
Receiver-operating characteristic (ROC) curve comparing N-terminal pro-B-type natriuretic peptide (NTproBNP), midregional pro-adrenomedullin (MR-proADM), and the combined predicted probabilities from a binary logistic model for prediction of death or heart failure.
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Figure 5 Kaplan-Meier Curve: MR-proADM Quartiles Stratified by NTproBNP
Quartiles of MR-proADM are shown predicting the primary end point of death or heart failure in patients stratified by NTproBNP less than or greater than the median. Abbreviations as in Figure 2.
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Figure 6 Three-Dimensional Bar Chart
Annual event rates for death and for death or heart failure in patients stratified by NTproBNP less than or greater than the median and by MR-proADM quartiles.Abbreviations as in Figure 2.
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