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The Reno-Protective Effect of Hydration With Sodium Bicarbonate Plus N-Acetylcysteine in Patients Undergoing Emergency Percutaneous Coronary Intervention

The RENO Study

Alejandro Recio-Mayoral, MD^_*,_*, Marinela Chaparro, MD^_*, Belén Prado, MD^_*, Rocío Cózar, MD^_*, Irene Méndez, MD^_*, Debasish Banerjee, MD, MRCP, Juan C. Kaski, MD, DM, DSc, José Cubero, MD^_* and Jose M. Cruz, MD^_*

^_* Department of Cardiology, Virgen Macarena University Hospital, Seville, Spain
Department of Renal and Transplantation
Division of Cardiac and Vascular Sciences, St. George's Hospital, University of London, London, United Kingdom

View larger version (19K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Volumes of Contrast Medium (ml) Correlated With Maximum Change in SCr 72 h After PCI The solid lines represent the point estimated, and the upper and lower lines represent 2 SD. PCI = percutaneous coronary intervention; SCr = serum creatinine.

View larger version (25K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Incidence of Contrast-Induced Nephropathy Based on the Criteria Used Cr = creatinine.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Evolution of GFR at Baseline (Before PCI) and Days 1, 2, 3, and 7 Data are mean ± 2 SD. GFR = glomerular filtration rate, estimated using the Levey formula (16); PCI = percutaneous coronary intervention.