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J Am Coll Cardiol, 2007; 49:784-789, doi:10.1016/j.jacc.2006.11.021 (Published online 6 February 2007).
© 2007 by the American College of Cardiology Foundation
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Wireless Acoustic Communication With a Miniature Pressure Sensor in the Pulmonary Artery for Disease Surveillance and Therapy of Patients With Congestive Heart Failure

Yoseph Rozenman, MD, FACC*,{dagger},*, Robert S. Schwartz, MD, FACC{ddagger}, Hetal Shah, MPharm§ and Keyur H. Parikh, MD, FACC§

* The Heart Institute, E. Wolfson Medical Center (affiliated with the Sackler Faculty of Medicine Tel-Aviv University), Holon, Israel
{dagger} Remon Medical Technologies, Caesarea, Israel
{ddagger} Minneapolis Heart Institute and Foundation, Minneapolis, Minnesota
§ The Heart Care Clinic, Ahmedabad, India


Figure 1
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Figure 1 Pressure-Monitoring System

The system comprises an implant (A) and an external communication/analysis unit (B).

 

Figure 2
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Figure 2 Angiographic Images During Device Implantation

(A) Human right pulmonary angiogram. (B) Angiography of the pig main pulmonary artery. Panels C and D are fluoroscopic images of the human and pig implants, respectively.

 

Figure 3
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Figure 3 Macroscopic View and Histologic Sections of the Implant After 6 Months

(A) Fluoroscopy of the implant in situ, after sacrifice. (B) Macroscopic view of the implant in the main pulmonary artery. Panels C and D are histologic sections at the level of the titanium case and the anchor, respectively.

 

Figure 4
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Figure 4 Bland-Altman Comparison of PA Pressures From the Implant and the Millar Catheter

Diastolic and pulse pulmonary artery (PA) pressures (A and B, respectively).

 

Figure 5
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Figure 5 PA Pressure Measurements in Humans

Panels A and B are typical waveforms obtained simultaneously from the Millar catheter and the implant. Note the respiratory variation in panel B. Panels C and D are Bland-Altman and linear regression comparisons (respectively) of implant and Millar pulmonary artery (PA) diastolic pressures.

 

Figure 6
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Figure 6 Congestive Heart Failure Decompensation (Example)

(A and B) Regular follow-up while the patient was clinically stable; (C) during admission; (D) after diuretic therapy. PA = pulmonary artery; PAD = pulmonary artery diastolic pressure.

 




 
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