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Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure

The STARS-BNP Multicenter Study

Patrick Jourdain, MD^_*,,,_*, Guillaume Jondeau, MD, PhD, François Funck, MD, Pascal Gueffet, MD^||, Alain Le Helloco, MD^¶, Erwan Donal, MD^¶, Jean F. Aupetit, MD^#, Marie C. Aumont, MD, Michel Galinier, MD, PhD^_**, Jean C. Eicher, MD, Alain Cohen-Solal, MD, PhD and Yves Juillière, MD, PhD

^_* René Descartes University, Paris, France
Georges Pompidou Hospital, Paris, France
Department of Cardiology, Bichat University Hospital, Paris, France
Department of Cardiology, Centre Hospitalier Universitaire de Lariboisière, Paris, France
Hospitalier de Rene Dubos, Pontoise, France
^|| Centre Hospitalier Universitaire de Nantes, Nantes, France
^¶ Centre Hospitalier Universitaire de Rennes, Rennes, France
^# Hopital Saint Luc Lyon, Lyon, France
^_** Department of Cardiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
Centre Hospitalier Universitaire de Dijon, Dijon, France
Department of Cardiology, Centre Hospitalier Universitaire de Vandoeuvre Les Nancy, Vandoeuvre Les Nancy, France

View larger version (20K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Number of Changes in Medical Therapy During the First 3 Months Changes were related to high brain natriuretic peptide (BNP) value according to protocol or clinical reasons.

View larger version (35K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Changes in Medical Therapy During the Titration Phase in BNP Group and Clinical Group Therapeutic modifications during titration phase. ACEI = angiotensin-converting enzyme inhibitor; BNP = brain natriuretic peptide.

View larger version (18K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Evolution of Systolic Blood Pressure, Heart Rate, Weight, and Creatininemia During the First 3 Months Hemodynamic and biological variations during titration phase. BNP = brain natriuretic peptide; M = month.

View larger version (12K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Event-Free (Hospital Stay for Heart Failure or Death Related to Heart Failure) Survival in the 2 Groups Event-free survival. BNP = brain natriuretic peptide.

View larger version (41K): [in this window] [in a new window] [Download PPT slide]   Figure 5 Plasma BNP Level in BNP Group During Titration Phase and % of Patients Reaching Target BNP Value BNP = brain natriuretic peptide; M = month.