Coronary Artery Calcification and Changes in Atheroma Burden in Response to Established Medical Therapies
Stephen J. Nicholls, MBBS, PhD, FRACP, FACC*, , ,*,
E. Murat Tuzcu, MD, FACC*,
Kathy Wolski, MPH*,
Ilke Sipahi, MD*,
Paul Schoenhagen, MD*, ,
Timothy Crowe, BS*,
Samir R. Kapadia, MD, FACC*,
Stanley L. Hazen, MD, PhD*,, and
Steven E. Nissen, MD, FACC*
* Cardiovascular Medicine
Cell Biology
Center for Cardiovascular Diagnostics and Prevention
Division of Radiology, Cleveland Clinic, Cleveland, Ohio
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Figure 1 Baseline Calcification and Arterial Remodeling
Percentage of subjects with a baseline calcium < median (solid bars) or  median (open bars) who showed constrictive or expansive remodeling at the site containing the greatest amount of plaque. *p < 0.05 for comparison between groups.
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Figure 2 Baseline Calcification and Substantial Change in Atheroma Burden
Mean baseline calcium index in subjects stratified according to degree of relative change in percentage atheroma volume (top) and mean ± 95% confidence interval baseline calcium index in subjects stratified according to whether they underwent substantial change (at least 5% change in percentage atheroma volume) or no substantial change (bottom). *p < 0.001 for comparison between groups.
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Figure 3 Baseline Calcification and Substantial Change in Atheroma Burden With Risk Factor Modification
Percentage of subjects with a baseline calcium index < median (solid bars) or median (open bars) who underwent substantial change in percentage atheroma volume stratified according to degree of modification of low-density lipoprotein (LDL) cholesterol, systolic blood pressure (SBP), or C-reactive protein (CRP). *p < 0.05, **p < 0.01, and ***p < 0.001 for comparison between groups.
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