Coronary Heart Disease in Patients With Diabetes
Part I: Recent Advances in Prevention and Noninvasive Management
Colin Berry, MD, PhD,
Jean-Claude Tardif, MD, FACC and
Martial G. Bourassa, MD, FACC*
Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada
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Figure 1 Cumulative Incidence of Diabetes According to Study Group
The incidence of diabetes differed significantly among the 3 groups (p < 0.001). Compared with placebo, the lifestyle intervention reduced the incidence of diabetes during follow-up by 58% (95% confidence interval [CI] 48% to 66%) and metformin reduced it by 31% (95% CI 17% to 43%). The incidence of diabetes was 39% lower (95% CI 24% to 51%) in the former than in the latter group. Reproduced from The Diabetes Prevention Program Research Group (66) with permission.
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Figure 2 Cumulative Incidence of Cardiovascular Outcomes
Cumulative incidence of the first of any of the predefined cardiovascular disease (CVD) outcomes (A) and of the first occurrence of nonfatal MI, stroke, or death from CVD (B). Compared with conventional treatment, intensive diabetic treatment reduced the risk of any predefined CVD outcome by 42% (95% confidence interval [CI] 9% to 63%; p = 0.02) (A) and reduced the risk of the first occurrence of nonfatal MI, stroke, or death from CVD by 57% (95% CI 12% to 79%; p = 0.02) (B). Reproduced from Nathan et al. (28) with permission.
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