Urocortin 2 Infusion in Healthy Humans
Hemodynamic, Neurohormonal, and Renal Responses
Mark E. Davis, MBChB*,
Christopher J. Pemberton, PhD,
Timothy G. Yandle, PhD,
Steve F. Fisher, DMLT,
John G. Lainchbury, MD,
Christopher M. Frampton, PhD,
Miriam T. Rademaker, PhD and
A. Mark Richards, MD, PhD
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
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Figure 1 Plasma UCN 2, cAMP, and cGMP Responses to UCN 2 Infusion
Plasma urocortin 2 (UCN 2), cyclic adenosine monophosphate (cAMP), and cyclic guanosine monophosphate (cGMP) responses (geometric mean and pooled 95% confidence intervals) to UCN 2 infusion in 8 healthy men.
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Figure 2 Cardiac Output, Heart Rate, and Systemic Vascular Resistance Responses to UCN 2 Infusion
Cardiac output, heart rate, and systemic vascular resistance responses (mean and pooled standard errors) to urocortin (UCN) 2 infusion in 8 healthy men. Lunch was given after the 4-h observations.
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Figure 3 Systolic, Mean Arterial, and Diastolic Blood Pressure and Pulse Pressure Responses to UCN 2 Infusion
Systolic, mean arterial, and diastolic blood pressure and pulse pressure responses (mean and pooled standard errors) to urocortin (UCN) 2 infusion in 8 healthy men. Lunch was given after the 4-h observations.
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Figure 4 LVEDV, LVESV, and LVEF Responses to UCN 2 Infusion
Left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), and ejection fraction (LVEF) responses (mean ± SEM) to urocortin (UCN) 2 infusion in 8 healthy men.
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Figure 5 E, Em, E/Em, and Sm Mitral Valve Tissue Velocity Responses to UCN 2 Infusion
Transmitral early diastolic flow velocity (E), early diastolic myocardial tissue velocity at the medial mitral valve annulus (Em), E/Em, and systolic myocardial (Sm) mitral valve tissue velocity responses (mean ± SEM) to urocortin (UCN) 2 infusion in 8 healthy men.
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Figure 6 PRA, Angiotensin II, Aldosterone, Epinephrine, and Norepinephrine Responses to UCN 2 Infusion
Plasma renin activity (PRA), angiotensin II, aldosterone, epinephrine, and norepinephrine (geometric mean and pooled 95% confidence intervals) responses to urocortin (UCN) 2 infusion in 8 healthy men.
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Figure 7 Urine Volumes and Excretion of Sodium, Potassium, and Creatinine Responses to UCN 2 Infusion
Urine volumes and excretion of sodium, potassium, and creatinine (mean ± SEM) responses to urocortin (UCN) 2 infusion in 8 healthy men.
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