Total Cholesterol Content of Erythrocyte Membranes Is Increased in Patients With Acute Coronary SyndromeA New Marker of Clinical Instability?
Dimitrios N. Tziakas, MD, PhD*,
Juan Carlos Kaski, MD, DSc, FACC*,*,
Georgios K. Chalikias, MD, PhD*,
Carlos Romero, MD ,
Salim Fredericks, PhD,
Ioannis K. Tentes, PhD ,
Alexandros X. Kortsaris, PhD,
Dimitrios I. Hatseras, MD, PhD and
David W. Holt, PhD
* Cardiovascular Biology Research Centre, Division of Cardiac and Vascular Sciences, St. George's, University of London, London, United Kingdom
Analytical Unit, Division of Cardiac and Vascular Sciences, St. George's, University of London, London, United Kingdom
University Cardiology Department, Democritus University of Thrace, Alexandroupolis, Greece
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Figure 1 Total Cholesterol Content of Erythrocyte Membranes in Stable CAD and ACS Patients
Box plots represent median, quartiles, and range values of total cholesterol content of erythrocyte membranes (CEM). Data do not reflect logarithmic transformation or covariate adjustment as assessed in the analysis of covariance model. ACS = acute coronary syndrome; CAD = coronary artery disease.
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Figure 2 Number of Patients With ACS in Each Decile of CEM
Deciles d1 through d10 correspond to the following values: <47.6 µg/mg, 47.6 to 60.7 µg/mg, >60.7 to 82 µg/mg, >82 to 103.6 µg/mg, >103.6 to 112.1 µg/mg, >112.1 to 132.4 µg/mg, >132.4 to 173.1 µg/mg, >173.1 to 212.6 µg/mg, >212.6 to 284.8 µg/mg, and >284.8 µg/mg, respectively. Bars represent number of ACS patients within each decile. Abbreviations as in Figure 1.
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Figure 3 ROC Analysis Regarding Predictive Accuracy for the Characterization of CAD Activity
The bold line represents receiver-operating characteristic curve (ROC) analysis for total cholesterol content of erythrocyte membranes. The continuous line represents ROC analysis for C-reactive protein (CRP) levels. The dotted line represents ROC analysis for 1/high-density lipoprotein (HDL) cholesterol levels. CAD = coronary artery disease.
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