Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation
Apoor S. Gami, MD*, ,
Dave O. Hodge, MS ,
Regina M. Herges, BS,
Eric J. Olson, MD, ,
Jiri Nykodym, BS*,,
Tomas Kara, MD*, and
Virend K. Somers, MD, PhD, FACC*,,||,*
* Division of Cardiovascular Diseases
Department of Internal Medicine
Department of Biostatistics
Division of Pulmonary and Critical Care Medicine
|| Division of Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota
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Figure 1 Incidence of AF Based on Presence or Absence of OSA
Cumulative frequency curves for incident atrial fibrillation (AF) for subjects <65 years of age with and without obstructive sleep apnea (OSA) during an average 4.7 years of follow-up. p = 0.002.
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Figure 2 Incidence of AF Based on the Severity of OSA and Obesity
Cumulative frequency of incident atrial fibrillation (AF) during an average 4.7 years of follow-up, based on interactions between the body mass index (BMI) and the apnea-hypopnea index (AHI). An AHI <5 represents no obstructive sleep apnea (OSA), an AHI 5 to 40 represents mild to moderate OSA, and an AHI >40 represents severe OSA. A BMI <25 represents normal weight, a BMI 25 to 30 kg/m2 represents overweight, and a BMI >30 kg/m2 represents obesity.
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