Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice
Shany Blum, MD, MSc*,
Roy Asaf*,
Julia Guetta, PhD*,
Rachel Miller-Lotan, PhD*,
Rabea Asleh, MSc*,
Ran Kremer, MD*,
Nina S. Levy, PhD*,
Franklin G. Berger, MD, PhD ,
Doron Aronson, MD ,
Xiaoming Fu, PhD ,
Renliang Zhang, PhD,
Stanley L. Hazen, MD, PhD and
Andrew P. Levy, MD, PhD, FACC*,*
* Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Department of Biological Sciences, University of South Carolina, Columbia, South Carolina
Department of Cardiology, Rambam Medical Center, Haifa, Israel
Department of Cardiovascular Medicine and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio
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Figure 1 Flow Diagram of Mice Completing the IR Protocol Used in This Study
Fifty-four haptoglobin (Hp) 1 diabetes mellitus (DM) mice and 46 Hp 2 DM mice completing the ischemia-reperfusion (IR) protocol as described in the Methods section were used for measuring infarct size, cytokines, labile plasma iron (LPI), and lipid peroxidation. Infarct size was measured both in mice that did and did not receive BXT. BXT-treated mice received BXT before undergoing the IR protocol and non-BXT treated mice underwent the IR protocol but did not receive BXT. The number of mice used for each measurement is shown. In addition to the mice shown in the figure, lipid peroxidation was also measured in 5 Hp 1 and 5 Hp 2 mice that did not undergo the IR protocol. IL = interleukin.
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