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Two-Year Follow-Up of the Quantitative Angiographic and Volumetric Intravascular Ultrasound Analysis After Nonpolymeric Paclitaxel-Eluting Stent Implantation

Late "Catch-Up" Phenomenon From ASPECT Study

Duk-Woo Park, MD^_*, Myeong-Ki Hong, MD^_*, Gary S. Mintz, MD, FACC, Cheol Whan Lee, MD^_*, Jong-Min Song, MD^_*, Ki-Hoon Han, MD^_*, Duk-Hyun Kang, MD^_*, Sang-Sig Cheong, MD, Jae-Kwan Song, MD, FACC^_*, Jae-Joong Kim, MD^_*, Neil J. Weissman, MD, FACC, Seong-Wook Park, MD, FACC^_* and Seung-Jung Park, MD, FACC^_*,_*

^_* Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul
GangNeung, Korea
Cardiovascular Research Foundation, New York, New York
Washington Hospital Center, Washington, DC

View larger version (10K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Comparison of the cumulative distribution of the minimal luminal diameter (MLD) between all 3 groups (A = placebo; B = low dose; C = high dose) before and after stenting and at 6-month and 2-year follow-up. Minimal luminal diameter by quantitative coronary angiographic analysis in each group showed significant changes over time (p < 0.001), and these serial changes of MLD were significantly different among the 3 groups (p = 0.002).

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Comparison of the percent of intimal hyperplasia (IH) (A,B,C) and the minimal lumen area (D,E,F) among all 3 groups after stenting (A and D) and at 6-month (B and E) and 2-year (C and F) follow-up. The percent IH was significantly different (p = 0.005) at 6 months, but similar (p = 0.2) at 2-year follow-up among the 3 groups.

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 3 The serial changes in reference segment external elastic membrane (EEM), plaque, and lumen and in intra-stent lumen and intimal hyperplasia areas from 6-month to 2-year follow-up are shown (A = placebo; B = low dose; C = high dose). Measurements were made every 1 mm.