Advertisement






Click here for more guidelines.
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 2007; 49:698-705, doi:10.1016/j.jacc.2006.06.082 (Published online 25 January 2007).
© 2007 by the American College of Cardiology Foundation
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Noma, K.
Right arrow Articles by Higashi, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Noma, K.
Right arrow Articles by Higashi, Y.

Roles of Rho-Associated Kinase and Oxidative Stress in the Pathogenesis of Aortic Stiffness

Kensuke Noma, MD, PhD*, Chikara Goto, RPT, MS, PhD*, Kenji Nishioka, MD*, Daisuke Jitsuiki, MD*, Takashi Umemura, MD*, Keiko Ueda, MD, PhD{dagger}, Masashi Kimura, MD, PhD{dagger}, Keigo Nakagawa, MD, PhD{dagger}, Tetsuya Oshima, MD, PhD{ddagger}, Kazuaki Chayama, MD, PhD{dagger}, Masao Yoshizumi, MD, PhD*, James K. Liao, MD§ and Yukihito Higashi, MD, PhD, FAHA*,*

* Cardiovascular Physiology and Medicine
{dagger} Medicine and Molecular Science
{ddagger} Clinical Laboratory Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
§ Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.


Figure 1
View larger version (9K):
[in this window]
[in a new window]
[Download PPT slide]
 
Figure 1 FBF Response to SNP

Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements. *p < 0.01 versus basal forearm blood flow (FBF) assessed by Bonferroni correction. SNP = sodium nitroprusside.

 

Figure 2
View larger version (9K):
[in this window]
[in a new window]
[Download PPT slide]
 
Figure 2 FBF Response to ACh

Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements. *p < 0.05; {dagger}p < 0.01 versus basal forearm blood flow (FBF) assessed by Bonferroni correction. ACh = acetylcholine.

 

Figure 3
View larger version (10K):
[in this window]
[in a new window]
[Download PPT slide]
 
Figure 3 FBF Response to Fasudil Alone and After Co-Infusion of L-NMMA

Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements in each group. *p < 0.01 versus basal forearm blood flow (FBF) of fasudil alone; {dagger}p < 0.01 versus basal FBF after co-infusion of N G-monomethyl-L-arginine (L-NMMA) assessed by Bonferroni correction.

 




 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement