Roles of Rho-Associated Kinase and Oxidative Stress in the Pathogenesis of Aortic Stiffness
Kensuke Noma, MD, PhD*,
Chikara Goto, RPT, MS, PhD*,
Kenji Nishioka, MD*,
Daisuke Jitsuiki, MD*,
Takashi Umemura, MD*,
Keiko Ueda, MD, PhD ,
Masashi Kimura, MD, PhD,
Keigo Nakagawa, MD, PhD,
Tetsuya Oshima, MD, PhD ,
Kazuaki Chayama, MD, PhD,
Masao Yoshizumi, MD, PhD*,
James K. Liao, MD and
Yukihito Higashi, MD, PhD, FAHA*,*
* Cardiovascular Physiology and Medicine
Medicine and Molecular Science
Clinical Laboratory Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
View larger version (9K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 FBF Response to SNP
Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements. *p < 0.01 versus basal forearm blood flow (FBF) assessed by Bonferroni correction. SNP = sodium nitroprusside.
|
|
View larger version (9K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 FBF Response to ACh
Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements. *p < 0.05; p < 0.01 versus basal forearm blood flow (FBF) assessed by Bonferroni correction. ACh = acetylcholine.
|
|
View larger version (10K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 FBF Response to Fasudil Alone and After Co-Infusion of L-NMMA
Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements in each group. *p < 0.01 versus basal forearm blood flow (FBF) of fasudil alone; p < 0.01 versus basal FBF after co-infusion of N
G-monomethyl-L-arginine (L-NMMA) assessed by Bonferroni correction.
|
|
|
