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Effectiveness of Physical Counterpressure Maneuvers in Preventing Vasovagal Syncope

The Physical Counterpressure Manoeuvres Trial (PC-Trial)

Nynke van Dijk, MD^_*,_*, Fabio Quartieri, MD, Jean-Jaques Blanc, MD, Roberto Garcia-Civera, MD, Michele Brignole, MD^||, Angel Moya, MD^¶, Wouter Wieling, MD, PhD^_* PC-Trial Investigators

^_* Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands
Department of Interventional Cardiology, Ospedale S. Maria Nuova, Reggio Emilia, Italy
Department of Cardiology, Hospital de la Cavale Blanche, Brest Cedex, France
Department of Cardiology, Hospital Clinico Universitario Valencia, Valencia, Spain
^|| Department of Cardiology, Ospedali del Tigullio, Lavanga, Italy
^¶ Department of Cardiology, Hospital General Vall d'Hebron, Barcelona, Spain

View larger version (24K): [in a new window]   Figure 1 Flow-chart of included patients.

View larger version (12K): [in a new window]   Figure 2 Number of recurrences during follow-up. Black columns = maneuvers; white columns = conventional therapy.

View larger version (18K): [in a new window]   Figure 3 Kaplan-Meier syncope-free survival curve of time to first syncopal recurrence. Log-rank statistic p = 0.018; hazard ratio 0.59 (0.38 to 0.92). PCM = physical counterpressure maneuvers.