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Amino-Terminal Pro-Brain Natriuretic Peptide, Renal Function, and Outcomes in Acute Heart Failure

Redefining the Cardiorenal Interaction?

Roland R.J. van Kimmenade, MD, PhD^_*, James L. Januzzi, Jr, MD^,_*, Aaron L. Baggish, MD, John G. Lainchbury, MD, Antoni Bayes-Genis, MD, PhD, A. Mark Richards, MD, PhD and Yigal M. Pinto, MD, PhD^_*

^_* Department of Cardiology, University Hospital Maastricht, Maastricht, the Netherlands
Department of Cardiology, Massachusetts General Hospital, Boston, Massachusetts
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Science, Christchurch, New Zealand
Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

View larger version (20K): [in a new window]   Figure 1 Survival curves of heart failure subjects in ICON (International Collaborative on NT-proBNP) as a function of glomerular filtration rate (GFR) and amino-terminal pro-brain natruiuretic peptide (NT-proBNP) concentration on admission (log-rank p < 0.001).

View larger version (27K): [in a new window]   Figure 2 Survival curves of heart failure subjects in ICON as a function of NT-proBNP concentration on admission and dynamic changes in renal function following presentation (log-rank p < 0.001). Abbreviations as in Figure 1.