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Biomaterials for the Treatment of Myocardial Infarction

Karen L. Christman, PhD^_* and Randall J. Lee, MD, PhD^_*,,,_*

^_* University of California-Berkeley and San Francisco Joint Bioengineering Graduate Group, Berkeley and San Francisco, California
Department of Medicine
Cardiovascular Research Institute, University of California-San Francisco, San Francisco, California

View larger version (27K): [in a new window]   Figure 1 Strategies for treatment of myocardial infarction using biomaterials. To date, 3 different biomaterial approaches are being examined for treatment of myocardial infarction. Polymer meshes can be sutured around the heart for use as a left ventricular (LV) restraint (a) to preserve LV geometry. In vitro engineered tissue involves culturing cells on a biomaterial scaffold in vitro and then implanting the tissue onto the epicardial surface (b). In situ engineered tissue can be achieved by injecting a biomaterial alone (d), or using an injectable scaffold as a delivery vehicle for cells (c) or therapeutic agents such as genes or proteins (e).