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Effects of Normal, Pre-Hypertensive, and Hypertensive Blood Pressure Levels on Progression of Coronary Atherosclerosis

Ilke Sipahi, MD^_*, E. Murat Tuzcu, MD, FACC^_*, Paul Schoenhagen, MD, Katherine E. Wolski, MPH^_*, Stephen J. Nicholls, MBBS, PhD, FACC^_*, Craig Balog, BS^_*, Timothy D. Crowe, BS^_* and Steven E. Nissen, MD, FACC^_*,_*

^_* Department of Cardiovascular Medicine
Departments of Cardiovascular Medicine and Diagnostic Radiology, Cleveland Clinic Foundation, Cleveland, Ohio

View larger version (8K): [in a new window]   Figure 1 Locally weighted scatterplot smoothing graph showing the relationships between systolic blood pressure (SBP) and the rate of progression of coronary atherosclerosis (n = 274). An SBP in the range of approximately 120 to 140 mm Hg corresponded to no net progression or regression of coronary disease. Values above this range were associated with progression and those below were associated with regression of disease.

View larger version (12K): [in a new window]   Figure 2 Progression rate of coronary artery disease according to Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) blood pressure categories. Error bars represent means and 95% confidence intervals. *The p values were obtained using rank transformed data and adjusting for baseline total atheroma volume, low-density lipoprotein (LDL)/high-density lipoprotein (HDL) cholesterol ratio, and triglycerides. ANCOVA = analysis of covariance.