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Peroxisome Proliferator-Activated Receptors at the Crossroads of Obesity, Diabetes, and Cardiovascular Disease

Andries J. Gilde, PhD^_*,, Jean-Charles Fruchart, PhD^_*,, and Bart Staels, PhD^_*,,,_*

^_* INSERM U545
Department of Atherosclerosis, Institut Pasteur de Lille
University of Lille 2, Lille, France

View larger version (28K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Schematic representation of the transcriptional action of peroxisome proliferator-activated receptors (PPARs) with their heterodimer partner retinoic X receptor (RXR) and their major physiological functions. *Major function for this isoform but not exclusive. L = ligand; PPRE = peroxisome proliferator-activated receptor-responsive element.