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Consumption of Saturated Fat Impairs the Anti-Inflammatory Properties of High-Density Lipoproteins and Endothelial Function

Stephen J. Nicholls, MBBS, PhD, FRACP, FACC^_*,, Pia Lundman, MD, PhD, FESC^_*,,, Jason A. Harmer, BSc (Hons), Belinda Cutri, BMedSc (Hons)^_*, Kaye A. Griffiths, DMU, Kerry-Anne Rye, PhD^_*, Philip J. Barter, MBBS, PhD, FRACP^_*,|| and David S. Celermajer, MBBS, PhD, FRACP^_*,,||,_*

^_* The Heart Research Institute, Sydney, Australia
Department of Medicine, University of Adelaide, Adelaide, Australia
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
Division of Medicine, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden
^|| Department of Medicine, University of Sydney, Sydney, Australia

View larger version (12K): [in a new window]   Figure 1 Expression of intercellular adhesion molecule-1 (ICAM-1) (A) and vascular cell adhesion molecule-1 (VCAM-1) (B) by activated human umbilical vein endothelial cells after incubation with high-density lipoprotein (HDL) isolated after a meal enriched with a polyunsaturated (open bars) or saturated (gray bars) fat. Cells were incubated with HDL at an apolipoprotein A-I concentration of 8 µmol/l. Results are expressed as percentage of expression in the presence of HDL isolated from fasting blood (solid bars) (mean ± SEM). For difference between the meals: *p = 0.007; **p = 0.005. A significant meal-time period interaction was found for both ICAM-1 (p = 0.01) and VCAM-1 (p = 0.04).