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2009 Appropriateness Criteria for Coronary Revascularization

Intensive Glycemic Control and the Prevention of Cardiovascular Events: Expert Consensus Document
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J Am Coll Cardiol, 2006; 48:206-214, doi:10.1016/j.jacc.2006.04.044 (Published online 9 May 2006).
© 2006 by the American College of Cardiology Foundation
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Post-Reperfusion Myocardial Infarction

Long-Term Survival Improvement Using Adenosine Regulation With Acadesine

Dennis T. Mangano, PhD, MD*, Yinghui Miao, MD, MS, Iulia C. Tudor, PhD, Cynthia Dietzel, MDfor the for the Investigators of the Multicenter Study of Perioperative Ischemia (McSPI) Research Group the Ischemia Research and Education Foundation (IREF)

Ischemia Research and Education Foundation (IREF), San Bruno, California


Figure 1
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  		Figure 1 Consort diagram for the study patients. *Myocardial infarction (MI) indicates large, acute ST-segment elevation MI requiring either: 1) the presence of a new Q-wave on electrocardiogram and new post-reperfusion elevation of the MB isoform of creatine kinase (≥100 ng/ml anytime after removal of cross clamp, with a bordering value of 50% or more; or ≥70% ng/ml anytime after 12 h after removal of cross clamp with a bordering value of 50% or more; or ≥70 ng/ml anytime after 36 h after removal of cross clamp); or 2) the presence of autopsy evidence of infarction. CABG = coronary artery bypass graft; CPB = cardiopulmonary bypass.

 

Figure 2
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  		Figure 2 Kaplan-Meier analysis of 2-year survival according to with or without postoperative myocardial infarction (MI) among the 2,698 study patients.

 

Figure 3
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  		Figure 3 (A) Kaplan-Meier analysis of 2-year survival according to the use or non-use of acadesine among the 100 study patients who sustained post-reperfusion myocardial infarction (MI). (B) Two-year mortality by-MI and by-treatment.

 

Figure 4
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  		Figure 4 Two-year mortality: acadesine versus placebo by patient characteristic. ASA = acetylsalicylic acid; BB = beta-blocker; CABG = coronary artery bypass graft; CCB = calcium channel blocker; CHF = congestive heart failure; DYS = dysrhythmia; HX = history of; LLA = lipid-lowering agents; MI = myocardial infarction; PTCA = percutaneous transluminal coronary angioplasty; UA = unstable angina.

 
 
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