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Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation

A Veterans Affairs Cooperative Studies Program Substudy

Steven N. Singh, MD^_*,_*, X. Charlene Tang, PhD, MD, Bramah N. Singh, MD, DSc, Paul Dorian, MD^_**, Domenic J. Reda, PhD, Crystal L. Harris, PharmD, Ross D. Fletcher, MD^_*, Satish C. Sharma, MD^||, J. Edwin Atwood, MD, Alan K. Jacobson, MD^¶, H. Daniel Lewis, Jr, MD^#, Becky Lopez, RN, Dennis W. Raisch, PhD, Michael D. Ezekowitz, MD, PhD SAFE-T Investigators

^_* Washington, DC
Hines, Illinois
West Los Angeles, California
Albuquerque, New Mexico
^|| Providence, Rhode Island
^¶ Loma Linda, California
^# Kansas City, Missouri
^_** University of Toronto, Toronto, Canada
Walter Reed Army Medical Center, Washington, DC
Lankenau Institute for Medical Research, Philadelphia, Pennsylvania

View larger version (48K): [in a new window]   Figure 1 Sinus rhythm (SR) versus atrial fibrillation (AF) comparisons on mean changes in quality-of-life scores from baseline to 8 weeks by presence of AF symptoms. *p 0.05; **p 0.01; ***p 0.001. (A) Symptomatic patients (SR group: n = 167; AF group: n = 179). (B) Asymptomatic patients (SR group: n = 116; AF group: n = 92). SCL = symptom checklist; SF-36 = Short Form-36.

View larger version (44K): [in a new window]   Figure 2 Sinus rhythm (SR) versus atrial fibrillation (AF) comparisons on comparison of mean changes in quality-of-life scores from baseline to 1 year by presence of AF symptoms. *p 0.05; **p 0.01; ***p 0.001. (A) Symptomatic patients (SR group: n = 202; AF group: n = 111). (B) Asymptomatic patients (SR group: n = 118; AF group: n = 65). SCL = symptom checklist; SF-36 = Short Form-36.

View larger version (19K): [in a new window]   Figure 3 Sinus rhythm (SR) versus atrial fibrillation (AF) comparisons on mean increase in maximal exercise duration from baseline to 8 weeks and from baseline to 1 year. SR group: n = 213; AF group: n = 145. SR group: n = 219; AF group: n = 113.