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J Am Coll Cardiol, 2006; 48:298-304, doi:10.1016/j.jacc.2006.03.038 (Published online 22 June 2006).
© 2006 by the American College of Cardiology Foundation
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Insulin Therapy Is Associated With Platelet Dysfunction in Patients With Type 2 Diabetes Mellitus on Dual Oral Antiplatelet Treatment

Dominick J. Angiolillo, MD, PhD, FACC*,*, Esther Bernardo, BSc{dagger}, Celia Ramírez, BSc{dagger}, Marco A. Costa, MD, PhD, FACC*, Manel Sabaté, MD, PhD{dagger}, Pilar Jimenez-Quevedo, MD{dagger}, Rosana Hernandez, MD, PhD{dagger}, Raul Moreno, MD{dagger}, Javier Escaned, MD, PhD{dagger}, Fernando Alfonso, MD, PhD{dagger}, Camino Bañuelos, MD{dagger}, Theodore A. Bass, MD, FACC*, Carlos Macaya, MD, PhD{dagger} and Antonio Fernandez-Ortiz, MD, PhD{dagger}

* Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida
{dagger} Cardiovascular Institute, San Carlos University Hospital, Madrid, Spain


Figure 1
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  		Figure 1 Platelet aggregation after 6 and 20 µM adenosine diphosphate (ADP) stimuli in noninsulin-treated diabetes mellitus (NITDM; open bars) and insulin-treated diabetes mellitus (ITDM; solid bars).

 

Figure 2
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  		Figure 2 Platelet aggregation after 6 (left) and 20 (right) µM adenosine diphosphate (ADP) stimuli in nondiabetic patients (NDM; dotted bars), noninsulin-treated diabetes mellitus (NITDM; open bars) and insulin-treated diabetes mellitus (ITDM; solid bars).

 




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