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Evaluation of Left Ventricular Systolic Function in Pediatric Sickle Cell Anemia Patients Using the End-Systolic Wall Stress-Velocity of Circumferential Fiber Shortening Relationship

Luke Lamers, MD^_*,_*, Greg Ensing, MD^_*, Ricardo Pignatelli, MD, Caren Goldberg, MD, MS^_*, Louis Bezold, MD, Nancy Ayres, MD and Robert Gajarski, MD^_*,

^_* Division of Pediatric Cardiology, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan
Division of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas

View larger version (11K): [in a new window]   Figure 1 Linear regression equation for the meridional end-systolic wall stress-velocity of circumferential fiber shortening (VCFc) relationship for the African American control population with ± 2 SDs onto which individual sickle cell anemia data points for the meridional end-systolic wall stress-VCFc relationship are plotted. Solid line = healthy African-American patients; VCFc = 1.48 to 0.007 (meridional end-systolic wall stress), r = 0.7; n = 50; X = sickle cell anemia patients, n = 57. LV = left ventricular.