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The Role of Clopidogrel in Early and Sustained Arterial Patency After Fibrinolysis for ST-Segment Elevation Myocardial Infarction

The ECG CLARITY–TIMI 28 Study

Benjamin M. Scirica, MD, MPH^_*,,_*, Marc S. Sabatine, MD, MPH^_*,, David A. Morrow, MD, MPH, FACC^_*,, C. Michael Gibson, MD, MSc, FACC^,, Sabina A. Murphy, MPH^_*,, Stephen D. Wiviott, MD^_*,, Robert P. Giugliano, MD, SM, FACC^_*,, Carolyn H. McCabe, BS^_*,, Christopher P. Cannon, MD, FACC^_*, and Eugene Braunwald, MD, MACC^_*,

^_* Brigham and Women's Hospital
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Department of Medicine, Harvard Medical School, Boston, Massachusetts

View larger version (20K): [in a new window]   Figure 1 Schema of the CLARITY–TIMI 28 trial. Determination of early reperfusion was assessed by analyzing ST-segment resolution and late patency by angiography (median 3.5 days after randomization). ECG = electrocardiogram.

View larger version (26K): [in a new window]   Figure 2 Rates of Thrombolysis In Myocardial Infarction (TIMI) flow grade according to both ST-segment resolution (STRes) and treatment strategy. p = 0.003 for interaction between STRes category and treatment. CI = confidence interval; OR = odds ratio.

View larger version (23K): [in a new window]   Figure 3 The rates of in-hospital cardiovascular death or myocardial infarction (MI) according to both ST-segment resolution (STRes) at 90 min and treatment strategy. p = 0.027 for interaction between STRes category and treatment. CI = confidence interval; OR = odds ratio.

View larger version (26K): [in a new window]   Figure 4 The rates of cardiovascular death or myocardial infarction (MI) (A) and cardiovascular death alone (B) at 30 days according to both ST-segment resolution (STRes) and treatment strategy. p = 0.026 for interaction between STRes category and treatment for death or MI and 0.179 for death alone. CI = confidence interval; OR = odds ratio.