Randomized Controlled Trial of the Effects of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery
First Clinical Application in Humans
Michael M.H. Cheung, MB, ChB, MRCP,
Rajesh K. Kharbanda, MD, PhD,
Igor E. Konstantinov, MD, PhD,
Mikiko Shimizu, MD,
Helena Frndova, Meng,
Jia Li, MD, PhD,
Helen M. Holtby, MD,
Peter N. Cox, MD,
Jeffrey F. Smallhorn, MD, FRCP,
Glen S. Van Arsdell, MD and
Andrew N. Redington, MD, FRCP*
Divisions of Cardiology and Cardiovascular Surgery, Critical Care Medicine and Anaesthesia, Hospital for Sick Children, Toronto, Canada
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Figure 1 Pre- and postoperative levels of troponin I in remote ischemic preconditioning (RIPC) and control groups.
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Figure 2 Postoperative inotrope scores in remote ischemic preconditioning (RIPC) and control groups.
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Figure 3 Airway resistance (RAW) in remote ischemic preconditioning (RIPC) and control groups.
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Figure 4 Levels of interleukin (IL)-10 at 3 h and tumor necrosis factor (TNF)-alpha at 6 h postoperatively in remote ischemic preconditioning (RIPC) and control groups.
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