Relationship Between Cardiovascular Risk Factors and Atherosclerotic Disease Burden Measured by Intravascular Ultrasound
Stephen J. Nicholls, MBBS, PhD*,
E. Murat Tuzcu, MD*,
Tim Crowe, BS*,
Ilke Sipahi, MD*,
Paul Schoenhagen, MD*,
Samir Kapadia, MD*,
Stanley L. Hazen, MD, PhD*,
Chuan-Chuan Wun, PhD ,
Michele Norton, PhD ,
Fady Ntanios, PhD and
Steven E. Nissen, MD*,*
* Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
Pfizer Pharmaceuticals, New York, New York

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Figure 1 Method for selection of cross sections for analysis. Cross sections are obtained for "slices" selected at 1-mm intervals (top). Three of the 48 cross sections illustrated for this vessel are shown at the bottom (cross sections 10, 26, and 48).
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Figure 2 Method for analysis of atheroma area. The left panel shows a representative intravascular ultrasound cross section. The right panel illustrates the boundaries planimetered for the external elastic membrane (EEM) and lumen. Atheroma area is calculated.
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