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Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction

Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction

Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece

View larger version (9K): [in a new window]   Figure 1 Serum levels of soluble CD40 ligand (sCD40L) were significantly higher in carriers of the 807T allele both during the acute phase of myocardial infarction (MI) and one year after the event in the same subjects, compared with 807CC homozygotes. Although sCD40L level was increased in all genotypes during the acute phase of MI compared with the values one year after the event, the increase in 807T carriers was greater than the increase in 807CC homozygotes (p < 0.05). Levels of sCD40L were similar between the genotypes in the control group. Solid bars = carriers of the 807T allele (807TT + 807CT); open bars = 807CC homozygotes. *p < 0.01 vs. CC; p < 0.01 vs. acute phase (after Bonferroni correction); p < 0.01 vs. controls (after Bonferroni correction).

View larger version (21K): [in a new window]   Figure 2 (A) In the control group, carriers of the 807T allele (807TT + 807CT) had significantly higher levels of soluble CD40 ligand (sCD40L) compared with 807CC homozygotes in the presence of high levels of von Willebrand factor (vWF median), while there was no difference in sCD40L between genotypes among healthy individuals with vWF < median (vWF median in controls: 72.84%). (B) Carriers of the 807T allele had significantly higher levels of sCD40L compared with 807CC one year after myocardial infarction (MI) independently from plasma vWF levels (vWF median for follow-up group: 87.1%). (C) Similarly, the presence of the 807T allele was associated with higher levels of sCD40L during the acute phase of MI, independently from vWF levels (median for vWF during the acute phase of MI: 92.12%). Solid bars = Carriers of the 807T allele (807TT + 807CT); open bars = 807CC homozygotes; *p < 0.05 and **p < 0.01 vs. carriers of T allele.