This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Anand, D. V. Articles by Corder, R. Search for Related Content PubMed PubMed Citation Articles by Anand, D. V. Articles by Corder, R.

The Relationship Between Plasma Osteoprotegerin Levels and Coronary Artery Calcification in Uncomplicated Type 2 Diabetic Subjects

Dhakshinamurthy Vijay Anand, MBBS, MRCP^_*,,,_*, Avijit Lahiri, MBBS, MSc, MRCP, FACC, FESC^_*, Eric Lim, MBChB, MA, MRCP^_*, David Hopkins, BSc, MBChB, FRCP and Roger Corder, PhD, MRPharmS

^_* Cardiac Imaging and Research Centre, Wellington Hospital
William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry
Department of Cardiology, Royal Free Hospital
Department of Endocrinology, Kings College Hospital, London, United Kingdom

View larger version (11K): [in a new window]   Figure 1 Box and whisker plots illustrate the median and interquartile ranges of osteoprotegerin (OPG) in patients with minimal, mild, moderate, severe, and extensive coronary calcification respectively. Open circles show outliers (values between 1.5 and 3 box lengths from the upper edge of the box) and asterisks show extreme outliers (values >3 box lengths from the upper edge of the box).

View larger version (12K): [in a new window]   Figure 2 The correlation between markers of inflammation (high-sensitivity C-reactive protein [hs-CRP, in mg/l], interleukin [IL]-6 [in pg/ml]) and the coronary calcium (CAC) score. Log transformation was applied to normalize the distribution of hs-CRP and IL-6 and to reduce the skew of CAC scores.

View larger version (9K): [in a new window]   Figure 3 Event-free survival at 18 ± 5 months by the Cox proportional hazards model according to the extent of coronary calcification level (A) and plasma osteoprotegerin (OPG) level (B), respectively. RR = relative risk ratio.

View larger version (19K): [in a new window]   Figure 4 Receiver-operating characteristic curve analysis showing the prognostic value of coronary calcium (CAC) scores, osteoprotegerin (OPG) levels, and United Kingdom Prospective Diabetes Study (UKPDS) and Framingham risk scores in predicting cardiovascular events. The 95% confidence intervals are provided. AUC = area under the curve.