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Aerobic Training Decreases B-Type Natriuretic Peptide Expression and Adrenergic Activation in Patients With Heart Failure

Claudio Passino, MD^_*,,_*, Silvia Severino, MS^_*, Roberta Poletti, MD^_*, Massimo F. Piepoli, MD, Chiara Mammini, MD^_*, Aldo Clerico, MD^_*,, Alessandra Gabutti, MD^_*, Guido Nassi, MS^_* and Michele Emdin, MD, PhD^_*

^_* Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
Scuba Superiore S. Anna, Pisa, Italy
G. da Saliceto Hospital, Piacenza, Italy

View larger version (16K): [in a new window]   Figure 1 Changes in exercise variables, resting heart rate, and neurohormones for trained (open circles) and untrained patients (closed circles) at baseline, three, and nine months. *p < 0.05, **p < 0.01, ***p < 0.001 versus baseline (significant values assessed by Bonferroni post-hoc test performed on three groups); #p < 0.05, ##p < 0.01 versus third month. BNP = brain natriuretic peptide; b.p.m. = beats/min; NT-proBNP = amino-terminal pro-brain natriuretic peptide; VO2 = oxygen uptake.

View larger version (10K): [in a new window]   Figure 2 Relation between the changes in peak oxygen uptake (VO2) and in plasma concentration of cardiac natriuretic peptides after training in group T patients. BNP = brain natriuretic peptide.