Time Dependence of Defibrillator Benefit After Coronary Revascularization in the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II
Ilan Goldenberg, MD*,*,
Arthur J. Moss, MD*,
Scott McNitt, MS*,
Wojciech Zareba, MD, PhD*,
W. Jackson Hall, PhD ,
Mark L. Andrews, BBS*,
David J. Wilber, MD ,
Helmut U. Klein, MD for the MADIT-II Investigators
* Cardiology Unit, Department of Medicine
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York
Cardiovascular Institute, Loyola University Medical Center, Maywood, Illinois
Division of Cardiology, University Hospital, Magdeburg, Germany
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Figure 1 Kaplan-Meier estimates of probability of all-cause mortality by treatment group among patients enrolled (A)  6 months after coronary revascularization (CR), (B) 7 to 60 months after coronary revascularization, and (C) >60 months after coronary revascularization. ICD = implantable cardioverter-defibrillator.
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Figure 2 Two-year Kaplan-Meier estimates of all-cause mortality in the two treatment groups by time from coronary revascularization. Solid bars = conventional (conv); open bars = implantable cardioverter-defibrillator (ICD).
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Figure 3 Kaplan-Meier estimates of probability of sudden cardiac death by treatment group among patients enrolled (A) 6 months after coronary revascularization (CR), (B) 7 to 60 months after coronary revascularization, and (C) >60 months after coronary revascularization. ICD = implantable cardioverter-defibrillator.
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Figure 4 The ratio of sudden cardiac death to all-cause mortality by elapsed time from coronary revascularization in the conventional therapy group; p = 0.18 for the comparison of the four time periods; p = 0.04 for the comparison of 6 months to >6 months. SCD = sudden cardiac death.
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