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Metabolic Syndrome and the Risk of Cardiovascular Disease in Older Adults

Javed Butler, MD, MPH, FACC^_*,_*, Nicolas Rodondi, MD, MAS^||, Yuwei Zhu, PhD, Kathleen Figaro, MD, MS, Sergio Fazio, MD, PhD^_*, Douglas E. Vaughan, MD, FACC^_*, Suzanne Satterfield, MD, Anne B. Newman, MD, MPH^#, Bret Goodpaster, PhD^#, Douglas C. Bauer, MD^||, Paul Holvoet, PhD^_**, Tamara B. Harris, MD, MS, Nathalie de Rekeneire, MD, Susan Rubin, MPH^¶, Jingzhong Ding, PhD, Stephen B. Kritchevsky, PhD the Health ABC Study

^_* Division of Cardiovascular Medicine
Department of Biostatistics
Division of General Internal Medicine, Vanderbilt University, Nashville, Tennessee
Department of Preventive Medicine, University of Tennessee, Memphis, Tennessee
^|| Department of Epidemiology and Biostatistics
^¶ Prevention Sciences Group, University of California San Francisco, San Francisco, California
^# Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
^_** Center for Experimental Surgery and Anesthesiology, Catholic University, Leuven, Belgium
Laboratory of Epidemiology, Demography and Biometry, National Institute of Aging, National Institutes of Health, Bethesda, Maryland
Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina

View larger version (15K): [in a new window]   Figure 1 Overall effect of metabolic syndrome (MetSyn) on cardiovascular outcomes and mortality. Point estimates of hazard ratios (HR) and 95% confidence intervals. Both unadjusted and covariate adjusted p values are shown. The covariates adjusted for included age, race (white and black), gender (male and female), smoking (never, past, and current), marital status (married, widow, and other), site (Memphis and Pittsburgh), and the presence of diabetes at baseline.

View larger version (20K): [in a new window]   Figure 2 Adjusted survival curves for myocardial infarction (MI), heart failure (CHF), coronary event, and overall hospital stay risk. The figures represent survival plots adjusted for age, gender, race, smoking status, marital status, site, and diabetes. Cum = cumulative; MetSyn = metabolic syndrome.