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A Common Polymorphism in the Complement Factor H Gene Is Associated With Increased Risk of Myocardial Infarction

The Rotterdam Study

Isabella Kardys, MD^_*, Caroline C.W. Klaver, MD, PhD^_*,, Dominiek D.G. Despriet, MD^_*,, Arthur A.B. Bergen, PhD^¶,||, André G. Uitterlinden, PhD, Albert Hofman, MD, PhD^_*, Ben A. Oostra, PhD, Cornelia M. Van Duijn, PhD^_*, Paulus T.V.M. de Jong, MD, PhD^_*,¶,# and Jacqueline C.M. Witteman, PhD^_*,_*

^_* Epidemiology & Biostatistics
Ophthalmology
Internal Medicine
Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands
^¶ Department of Ophthalmogenetics, Netherlands Ophthalmic Research Institute, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands
^|| Clinical Genetics
^# Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands

View larger version (14K): [in a new window]   Figure 1 Flow chart describing study population. CFH = complement inhibitor factor H; DNA = deoxyribonucleic acid.

View larger version (18K): [in a new window]   Figure 2 Age- and gender-adjusted event-free survival until incident myocardial infarction.

View larger version (27K): [in a new window]   Figure 3 Age- and gender-adjusted hazard ratios for myocardial infarction according to Tyr402His genotype in subgroups, created according to median values for continuous variables. BMI = body mass index; CRP = C-reactive protein; HDL = high-density lipoprotein.