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Impact of Body Mass Index on Cardiac Mortality in Patients With Known or Suspected Coronary Artery Disease Undergoing Myocardial Perfusion Single-Photon Emission Computed Tomography

Xingping Kang, MD^_*, Leslee J. Shaw, PhD, FACC^_*,, Sean W. Hayes, MD^_*,, Rory Hachamovitch, MD, MSc, FACC, Aiden Abidov, MD, PhD^_*, Ishac Cohen, PhD^_*, John D. Friedman, MD, FACC^_*,, Louise E.J. Thomson, MB^_*,, Donna Polk, MD, MPH, FACC^_*,, Guido Germano, PhD, FACC^_*, and Daniel S. Berman, MD, FACC^_*,,_*

^_* Department of Imaging (Division of Nuclear Medicine), Department of Medicine (Division of Cardiology), and CSMC Burns & Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California
Department of Medicine, University of California at Los Angeles, School of Medicine, Los Angeles, California
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

View larger version (11K): [in a new window]   Figure 1 Annual rates of cardiac death in patients with known coronary artery disease by normal weight (open bars), overweight (gray bars), and obese (black bars) as a function of myocardial perfusion single-photon emission computed tomography results. *p < 0.001 across scan categories; p < 0.01 across weight categories. Abnl = abnormal; Mod = moderate; Sev = severe.

View larger version (11K): [in a new window]   Figure 2 Annual rates of cardiac death in patients with suspected coronary artery disease by normal weight (open bars), overweight (gray bars), and obese (black bars) as a function of myocardial perfusion single-photon emission computed tomography results. *p < 0.001 across scan categories. Abnl = abnormal; Mod = moderate; Sev = severe.

View larger version (9K): [in a new window]   Figure 3 Annual rates of cardiac death in patients with gated myocardial perfusion single-photon emission computed tomography by normal weight (open bars), overweight (gray bars), and obese (black bars) in normal and abnormal ejection fraction groups. *p = 0.001 across weight categories. EF = ejection fraction.

View larger version (7K): [in a new window]   Figure 4 Risk-adjusted survival curves for cardiac death by categories of weights in women with known coronary artery disease undergoing adenosine myocardial perfusion single-photon emission computed tomography. Marked differences were noted, with the highest survival in obese women, and the lowest survival in normal weight women. p < 0.001 across groups.

View larger version (6K): [in a new window]   Figure 5 Risk-adjusted survival curves for cardiac death by categories of weights in women with suspected coronary artery disease undergoing adenosine myocardial perfusion single-photon emission computed tomography. There were no significant differences between obese and non-obese patients. p = NS for all comparisons.