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B-Type Natriuretic Peptide Strongly Reflects Diastolic Wall Stress in Patients With Chronic Heart Failure

Comparison Between Systolic and Diastolic Heart Failure

Yoshitaka Iwanaga, MD^_*,_*, Isao Nishi, MD^_*, Shinichi Furuichi, MD^_*, Teruo Noguchi, MD^_*, Kazuhiro Sase, MD^_*, Yasuki Kihara, MD, FACC, Yoichi Goto, MD^_* and Hiroshi Nonogi, MD^_*

^_* Division of Cardiology, National Cardiovascular Center, Suita, Japan
Department of Cardiovascular Medicine, Kobe City General Hospital, Kobe, Japan

View larger version (38K): [in a new window]   Figure 1 Correlation between B-type natriuretic peptide (BNP) and left ventricular functional parameters in all 160 patients. (A) Left ventricular ejection fraction (EF) (%). (B) End-diastolic pressure (EDP) (mm Hg). (C) End-systolic wall stress (SWS) (kdynes/cm2). (D) End-diastolic wall stress (EDWS) (kdynes/cm2).

View larger version (25K): [in a new window]   Figure 2 Differences of B-type natriuretic peptide (BNP) and left ventricular functional parameters between systolic heart failure (SHF) (n = 98) and diastolic heart failure (DHF) (n = 62). The box defines the interquartile range with the median indicated by the crossbar. The error bars indicate the 10th and 90th percentiles. EDP = end-diastolic pressure (mm Hg); EDVI = end-diastolic volume index (ml/m2); EDWS = end-diastolic wall stress (kdynes/cm2); SWS = end-systolic wall stress (kdynes/cm2).

View larger version (38K): [in a new window]   Figure 3 Correlation between B-type natriuretic peptide (BNP) and left ventricular functional parameters in 98 patients with systolic heart failure (SHF) (A and B) and in 62 patients with diastolic heart failure (DHF) (C and D); (A and C) end-diastolic pressure (EDP) (mm Hg) and (B and D) end-diastolic wall stress (EDWS) (kdynes/cm2).