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Coronary Endothelial Vasomotor Function and Vascular Remodeling in Heart Transplant Recipients Randomized for Tacrolimus or Cyclosporine Immunosuppression

Paraskevi Petrakopoulou, MD^_*, Lydia Anthopoulou, MD, Michael Muscholl, MD^_*, Volker Klauss, MD, Wolfgang von Scheidt, MD^¶, Peter Überfuhr, MD, Bruno M. Meiser, MD, Bruno Reichart, MD and Michael Weis, MD^_*,_*

^_* Medizinische Klinik und Poliklinik I
Herzchirurgische Klinik, Klinikum Grosshadern
Mathematisches Institut
Medizinische Poliklinik des Klinikum Innenstadt; Ludwig-Maximilians University of Munich, Munich, Germany
^¶ Zentralklinikum Augsburg, Augsburg, Germany

View larger version (5K): [in a new window]   Figure 1 Mean intimal area (left anterior descending artery) detected by intravascular ultrasound. The mean intimal area significantly increased in the cyclosporin A (open bars) versus the tacrolimus (closed bars) group during follow-up (change from baseline to follow-up: p < 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.

View larger version (5K): [in a new window]   Figure 2 Mean vessel area (left anterior descending [LAD]) detected by intravascular ultrasound. The mean vessel area significantly increased in the tacrolimus (closed bars) versus the cyclosporin A (open bars) group during follow-up (change from baseline to follow-up: p < 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.

View larger version (5K): [in a new window]   Figure 3 Circulating plasma endothelin 1 (ET-1) concentrations (radioimmunoassay). The circulating ET-1 concentration in the tacrolimus (closed bars) (but not in the cyclosporin A [open bars]) group decreased during the first 12 postoperative months. The absolute change in ET-1 concentration during follow-up was significantly different between the groups (p 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.