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Accuracy of 64-Slice Computed Tomography to Classify and Quantify Plaque Volumes in the Proximal Coronary System

A Comparative Study Using Intravascular Ultrasound

Alexander W. Leber, MD^_*,,_*, Alexander Becker, MD^_*, Andreas Knez, MD^_*, Franz von Ziegler, MD^_*, Marc Sirol, MD, Konstantin Nikolaou, MD, Bernd Ohnesorge, PhD, Zahi A. Fayad, PhD, Christoph R. Becker, MD, Maximilian Reiser, MD, Gerhard Steinbeck, MD^_* and Peter Boekstegers, MD^_*

^_* Department of Cardiology
Institute for Diagnostic Radiology, Klinikum Grosshadern, University of Munich, Munich, Germany
Siemens Medical Solutions CT-Division, Forchheim, Germany
Mount Sinai Medical Center New York, Imaging Science Laboratory, New York, New York

View larger version (20K): [in a new window]   Figure 1 Bland-Altman plot (A) and correlation graph (B) for plaque volumes per vessel determined by intravascular ultrasound (IVUS) versus 64-slice computed tomography (SCT). Vessel plaque volume is underestimated systematically by 64-slice computed tomography (p < 0.05), and correlation is moderate (Spearman correlation coefficient r2 = 0.69).

View larger version (108K): [in a new window]   Figure 2 Lipid core within a mixed plaque detected by intravascular ultrasound (IVUS) and 64-slice computed tomography (CT). ca = calcium; lc = lipid core.

View larger version (79K): [in a new window]   Figure 3 Noncalcified section with an embedded lipid core indicated by echolucency on intravascular ultrasound (IVUS) and hypodensity on 64-slice computed tomography (CT).